Viruses, as obligate intracellular parasites, need to subvert the host cell in order to enable their replication and efficient spread. Due to strict restrictions in genome size, viruses commonly produce a limited number of proteins; this is the case of geminiviruses, plant viruses with circular single-stranded (ss)DNA genomes that are believed to contain only 4-8 translated open reading frames. Strikingly, despite their limited armoury, geminiviruses are able to establish an infection, overcoming plant defence, dramatically altering plant development and physiology, and ultimately causing devastating diseases to crops worldwide. How these viruses successfully invade and manipulate their plant hosts by deploying only a handful of proteins is a long-standing, fascinating question. In our group, we are interested in understanding how geminiviruses co-opt the plant cell and lead to disease, for which we use a combination of approaches, including molecular biology, cell biology, and genetics. Our results have shed light onto the molecular mechanisms underlying the replication of viral DNA, plant anti-viral defence and geminiviral counter-defence, and symptom development, and hint at novel virulence strategies potentially employed by geminiviruses to maximize their coding capacity and their impact on the host cell. We expect that our work will contribute to a deeper understanding of the infection process, which may in turn pave the way to the design of effective and sustainable anti-viral strategies and assist breeding programs to obtain virus-resistant plants.