Peptides signals have been identified to be involved in multiple developmental processes and stress responses in plants. A number of peptide signals have been characterized to be key regulators of plant senescence and complex regulatory networks involving peptides from different families are getting unveiled. The CLE14 peptide functions as a ”brake signal” of leaf senescence at late developmental stages via activating the expression of NAC family transcription factor JUB1 which pays a role in suppressing ROS accumulation during senescence. The IDL6 peptide on the other hand, promotes senescence of Arabidopsis leaves. More interestingly, SCOOP10 and SCOOP12, two peptides from the same family, compete for the same receptor in regulating leaf senescence: SCOOP10 promotes senescence at early stages and SCOOP12 expression is activated at late stages to suppress senescence, similar to CLE14, to ensure an orderly senescence process which is critical in remobilizing nutrients from senescing leaves to sink tissues.