The inhibitor of virus replication (IVR) is a well-established plant protein shown to effectively combat infection by numerous plant viruses. In our recent study, IVR has shown that it is a part of a novel resistance pathway mediated by the transcription factor (TF) Signaling Hub Effector 1 (SHE1), induced by Tobacco mosaic virus infection in N gene tobacco. SHE1 interacts with IVR both in vivo and in vitro. Additionally, IVR interacts with the 1a protein encoded in RNA 1 of cucumber mosaic virus (CMV), suggesting that this replication-associated protein is a target for IVR. The IVR modeled structure is identical to the C-terminal third of anaphase-promoting complex 7 (APC7), part of the cellular cyclosome, a 13-subunit E3-ubiquitin ligase controlling mitotic division progression. APC7, including IVR, contains putative promoter sites for various TFs, including SHE1. We suggest that these sequences within the APC7 gene facilitate the induction of expression of IVR by SHE1 to serve a novel function in plant defense.