Plants use cell surface and intracellular immune receptors to recognize pathogens. Plasma membrane receptors sense microbe-derived molecules to confer pattern-triggered immunity (PTI), while intracellular receptors recognize microbial effectors and confer effector-triggered immunity. Both branches of the plant immune system converge in signal transduction upstream of nuclear events. We report here new molecular insights into the EDS1-PAD4-ADR1 node as a convergence point of immune signalling mediated by both surface-resident and intracellular immune receptors. In particular, we highlight the importance of phosphoribosyl-AMP/ADP in the activation of early events implicated in the activation of PTI.